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Book Information

Publisher:New Age International (P) Ltd.
Published In:2008
ISBN-10:8122409245
ISBN-13:9788122409246
Binding Type:Paperback
Weight:1.88 lbs
Pages:pp. 632, Figures, Tables, Index, Appendices, References, Acknowledgement

The Title "A Textbook of Medicinal Biochemistry 1st Edition, Reprint" is written by R.L. Nath. This book was published in the year 2008. The ISBN number 8122409245|9788122409246 is assigned to the Paperback version of this title. The book displayed here is a 1st Edition, Reprint edition. This book has total of pp. 632 (Pages). The publisher of this title is New Age International (P) Ltd.. We have about 2595 other great books from this publisher. A Textbook of Medicinal Biochemistry 1st Edition, Reprint is currently Available with us.

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About the Book

This Book covers the syllabus of Biochemistry prescribed by different Indian Universities for the preclinical students of Medical colleges. It is intended to provide a broad knowledge of General Biochemistry with essentials of some rapidly advancing fields like Immunochemistry, Nucleic acids, Protein synthesis and Gene expression.

The book includes relevant basic physical Chemistry and organic chemistry with detailed presentation of the biomolecules together with structure and function of the living cell. The special factors involved in biochemical reactions are dealt with for their chemical nature and mechanism of action based on current advances of molecular basis.

General metabolic reactions are explained diagrammatically with up-to-date information in terms of structure of molecules. Metabolic changes under special conditions like starvation, high altitude, deep sea diving, astronautical flights, Sports and disease conditions are included.

A correlating link has been maintained throughout with Clinical Medicine wherever applicable. Digestion, absorption, organ functions and changes of blood constitutions in diseases are given with sufficient details for an easy follow-up in contemporary and future subjects of study by the students in the medical course.

Medicinal subjects, not usually included in General Biochemistry such as contraception, toxicology. Nutrition radioisotopes and antimetabolites are also described with enough fundamentals for a thorough understanding.

About the Author

The Johns Hopkins University ondon University for his pioneering research on the electronic nechanism of enzyme action using ?-D-glycosidase from emulsin. His continued research on enzymes carried out in India for nearly 20 years brought him international recognition. Other areas of his research include development of methodology suited to Indian conditions in clinical Biochemistry, determination of normal ranges of biochemical constituents in body fluids for local population, carbohydrate metabolism,clinic biochemical studies on diseases like diabetes mellitus, coronary heart disease and nephritic syndrome as well as on the possible applicability of steroids in the treatment of meningitis collaboration with the Johns Hopkins University of USA.

He has to his credit about 155 Research Publications in India and abroad besides a book ‘Practice of Biochemistry in Clinical Medicine’ (1976, enlarged second edition, 1990) with up-to-date technique for clinical investigations and interpretation of results. It was the first book of its kind in India. Besides various honours in India including UGC award as an eminent retired teacher, Dr. Nath has been cited in such international biographies as World Who’s Who in Science-from antiquity to the present’ (1968), ‘Who’s Who in the World’ (1974-75) and ‘International Directory of Distinguished Leadership’ (1996) in USA and also in ‘Dictionary of International Biography’ (1974-75) and ‘Men of Achievement’ (1976) in UK. He was a collaborator of Enzymologia for 9 years. Dr. Nath has taught Chemistry, Biochemistry and Chemical Pathology to medical students and performed/supervised biochemical investigations for patients for nearly 50 years (1939-88). He served as Professor and head of the Department of Biochemistry in the renowned postgraduate medical institute, the school of Tropical Medicine, Calcutta. After retirement, he joined the R.K. Mission Seva Pratishthan, a general hospital, as Head of Biochemistry Department and Consultant in Biochemistry; he was subsequently appointed as Professor of the Vivekananda Institute of Medical Sciences holding the post till 1988. He served the University College of Medicine, Calcutta as extra mural professor teaching Clinical Biochemistry in the post-graduate classes for nearly 7 years.

His deep Insight into the inadequacies in the teaching of Biochemistry. responsible for students’ poor understanding of the role of basic sciences in Clinical medicine and associated subject. has induced him to write the present theoretical treatise. Medical graduates without specialization will benefit from the fundamental pre-requisites and continuation links provided between Biochemistry, Clinical Medicine and allied subjects of the medical sciences.

Contents

Chap. I : INTRODUCTION :
1. Biochemistry and Social Science
2. Biochemistry and Biological Sciences
3. Human Biochemistry and Other Biosciences
4. Prerequisites for Learning Biochemistry
5. Important Tools and Methods Employed in Biochemistry

Chap. II : SOME FUNDAMENTAL ASPECTS IN CHEMISTRY :
1. Atomic Structure
2. Electronic Theory of Valency and Chemical Bonds
3. Chemical Energetics
4. Valency of Carbon Atom and Some Special Features of its Compounds
5. Dissociation of Water and Electrolytes
6. Colloids and Some Membrane Phenomena
7. Surface Tension
8. Adsorption
9. Viscosity

Chap. III : FLUID ELECTROLYTE HOMEOSTASIS IN THE BODY :
1. Role of Water
2. Electrolytes in the Body
3. Hydrogen Ion Concentration and Buffers
4. Regulation of Blood Ph
5. Disorders of Acid-base Balance-Acidosis and Alkalosis

Chap. IV : THE CELL :
1. Classification
2. Cell Membrane
3. Cytoplasm
4. Nucleus
5. Mitochondria
6. Endoplasmic Reticulum (Ergastoplasm)
7. Ribosomes
8. Golgi Bodies
9. Lysosomes
10. Peroxisomes
11. Filaments
12. Microtubules
13. Cilia and Flagella
14. Comparison between Prokaryotic and Eukaryotic Cells
15. Some Differences between Plant Cells and Animal Cells
16. Viruses

Chap. V : ENZYMES :
1. Introduction
2. Classification
3. Characteristics
4. Repression and Induction of Enzyme Synthesis
5. Hormonal Control of Enzyme Activity
6. Isoenzymes (Isozymes)
7. Plasma Enzymes
8. Enzymes Kinetics
9. Mechanism of Enzyme Substrate Complex Formation

Chap. VI : CHEMISTRY OF CARBOHYDRATES :
1. Introduction
2. Monosaccharides
3. Oligosaccharides
4. Polysaccharides

Chap. VII : CHEMISTRY OF LIPIDS :
1. Introduction
2. Classification
3. Fatty Acids
4. Triglycerides (Triacylglycerols)
5. Waxes
6. Phospholipids (Phosphatides)
7. Sphingosine Lipids
8. Eicosanoids
9. Steroids

Chap. VIII : CHEMISTRY OF AMINO ACIDS AND PROTEINS :
1. Introduction
2. Amino Acids
3. Polypeptides
4. Proteins
5. Classification of Proteins
6. Properties of Proteins

Chap. IX : HORMONES :
1. Introduction
2. Classification
3. Mechanism of Action-Receptor Concept
4. Thyroid Hormones
5. Hormones of the Parathyroid Gland
6. Hormones of the Adrenal Glands
7. Hormones of the Gonads
8. Hormones of the Hypothalamus and the Pituitary
9. Hormones of the Pancreas
10. Hormones of the Gastrointestinal Tract

Chap. X : VITAMINS AND COENZYMES :
1. Introduction to Vitamins
2. Fat Soluble Vitamins
3. Water Soluble Vitamins
4. Introduction to Coenzymes
5. NAD+ and NADP+ (Nicotinamide Adenine Dinucleotide and Nicotinamide Adenine Dinucleotide Phosphate)
6. FMN and FAD (Flavin Mononucleotide and Flavin Adenine Dinucleotide)
7. Pyridoxal Phosphate
8. Tetrahydrofolic Acid (THF or FH4) and One Carbon Metabolism
9. Cobamides
10. Adenosine Triphosphate (ATP) and Adenosine Diphosphate (ADP)
11. Cytidine Diphosphate (CDP) and Uridine Diphosphate (UDP)
12. Coenzyme A (CoA)
13. Ubiquinone (Coenzyme Q or CoQ)
14. Thiamin Pyrophosphate (TPP) and Lipoic Acid
15. Other Coenzymes

Chap. XI : BIOENERGETICS AND BIOLOGICAL OXIDATION :
1. Application of Thermodynamics in Biological Reactions
2. Biological Oxidation Reduction

Chap. XII : THE ALIMENTARY SYSTEM :
1. Introduction
2. The Mouth (Oral Cavity)
3. The Stomach
4. The Small Intestines Duodenum, Jejunum and Ileum
5. The Colon (Large Intestines)
6. Disorders in the Alimentary Tract

Chap. XIII : METABOLISM OF CARBOHYDRATES :
1. Carbohydrates in Living Systems
2. Metabolism of Monosaccharides
3. Energetics of Physiological Oxidation of Carbohydrates
4. Gluconeogenesis
5. Disorders of Carbohydrate Metabolism

Chap. XIV : METABOLISM OF LIPIDS :
1. Introduction
2. Digestion and Absorption of Lipids
3. Role of the Liver
4. Role of Adipose Tissues
5. Oxidation of Fatty Acids ((3-oxidation)
6. Energetics of Fatty Acid Oxidation
7. Biosynthesis of Saturated Fatty Acids
8. Polyunsaturated Fatty Acids (Essential Fatty Acids)
9. Ketone Bodies and Ketosis
10. Metabolism and Cholesterol
11. Disorders of Lipid Metabolism

Chap. XV : METABOLISM OF AMINO ACIDS AND PROTEINS :
Metabolism of Amino Acids :
1. General Considerations
2. Metabolism of Individual Amino Acids

Metabolism of Proteins :
3. General Considerations
4. A Look into the Special Significance of the Chapter

Chap. XVI : NUCLEIC ACIDS AND PROTEIN BIOSYNTHESIS :
Nucleic Acids :
1. General Considerations
2. Structure of the Components
3. Biosynthesis and Degradation of Pyrimidine and Purine Nucleotides
4. Disorders Related to Purine Metabolism
5. Structure and Properties of DNA
6. Replication of DNA
7. Repair of DNA
8. Structure and Function of RNA
9. Biosynthesis of RNA

Biosynthesis of Proteins :
10. Heredity and the Gene
11. Genetic Abnormality and Diseases

Chap. XVII : INTEGRATION OF METABOLISM OF CARBOHYDRATES, LIPIDS AND PROTEINS AND ADAPTATION UNDER STARVATION :
1. Integration in Normal Conditions
2. Adaptation under Starvation
3. Adaptation under Heavy Exercise
4. Special Requirement of Glucose by Brain

Chap. XVIII : METABOLISM OF SOME INORGANIC CONSTITUENTS :
1. Sodium, Potassium and Chlorine
2. Calcium
3. Phosphorus
4. Iron
5. Magnesium
6. Iodine
7. Sulphur
8. Copper
9. Zinc
10. Manganese
11. Cabalt
12. Molybdenum
13. Selenium
14. Fluorine
15. Chromium

Chap. XIX : PORPHYRINS AND HEMOGLOBINS :
1. Porphyrins
2. Hemoglobin (Hb)
3. Problems and Adaptations at High Altitudes

Chap. XX : THE IMMUNE SYSTEM :
1. Protective Processes of the Body Against External Infection
2. Immunity and Antigens
3. Humoral System of Immunity Development and Antibodies
4. Role of Complements
5. Cellular System of Immunity Development
6. Histocompatibility Antigens
7. Autoimmunity
8. Sensitivity-Allergy

Chap. XXI : NERVOUS CONDUCTION AND MUSCULAR CONTRACTION :
Nervous Conduction :
1. Some General Considerations on Nerves
2. Structure of Nerve Cellus
3. Function of Nerves

Muscular Contraction :
4. Structure of Muscles
5. Contraction of Muscles
6. Metabolism in Muscles

Chap. XXII : DETOXICATION :
1. General Considerations
2. Types of Reactions in Detoxication

Chap. XXIII : FUNCTIONS OF SOME ORGANS AND THEIR TESTS :
1. Introduction
2. Liver Function Tests
3. Renal Function Tests
4. Tests on the Function of the Upper Gastrointestinal Tract
5. Tests on the Function of the Lower Gastrointestinal Tract
6. Thyroid Function Tests
7. Biochemical and Physiological Changes in Astronauts

Chap. XXIV : NUTRITION :
1. Introduction
2. Energy Requirement of the Body
3. Nutritional Utility of Different Food Principles
4. Balanced Diet
5. Nutrition Dependent Disorders

Chap. XXV : THE BLOOD :
1. General Considerations
2. Functions of Blood
3. Some Important Features of Blood
4. The Formed Elements of Blood (Cells)
5. Blood Proteins
6. Blood Coagulation
7. Disorders related to Defects in Blood Coagulation
8. Normal Ranges of Some Important Blood Constituents

Chap. XXVI : ANTIMETABOLITES :
1. General Considerations
2. Sulphonamides
3. Antibiotics
4. Antimetabolites in Cancer Therapy

Chap. XXVII : FERTILITY CONTROL :
1. General Considerations
2. Methods of Contraception
3. Range of Failure Rates by Different Methods of Fertility Control
4. Future Developments
5. Special Conditions in India and Other Countries of the Third World

Chap. XXVIII : RADIOISOTOPES :
1. General Considerations
2. Artificial Radioactive Isotopes
3. Tracer Technique
4. Application of Radioelements
5. Radiation Hazards and Safety Measures